Open AccessJournal ArticleDOI
Marzanna Obrzut, +8 moreMayo Clinic,UPRRP College of Natural Sciences,Rzeszów University
- 21 Oct
2020-
Scientific Reports
- Vol. 10, Iss: 1, pp 17887-17887
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9Citations
TL;DR: Assessment of the normative values of liver R2* in healthy individuals with a high proportion of young women found that in the absence of fibrosis or steatosis, liver stiffness and fat fraction did not show any relationship with R2*.
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Abstract:Iron overload is a relatively common clinical condition resulting from disorders such as hereditary hemochromatosis, thalassemia, sickle cell disease, and myelodysplasia that can lead to progressive fibrosis and eventually cirrhosis of the liver. Therefore, it is essential to recognize the disease process at the earliest stage. Liver biopsy is the reference test for the assessment of liver fibrosis. It also allows for quantifying liver iron concentration (LIC) in patients. However, this is an invasive method with significant limitations and possible risks. Magnetic resonance imaging (MRI) and evaluation of the R2* relaxation rate can be an alternative to biopsy for assessing LIC. However, it causes a need for accurate R2* data corresponding to standard value for further comparison with examined patients. This study aimed to assess the normative values of liver R2* in healthy individuals. A total of 100 volunteers that met established criteria were enrolled in the study: 36 (36%) men and 64 (64%) women. The mean age was 22.9 years (range 20 to 32 years). R2* was estimated by an MRI exam with a 1.5 T clinical magnetic resonance scanner. Images for measuring the LIC and liver fat concentration were obtained using the IDEAL-IQ technique for liver imaging. The Mean (SD) liver R2* was 28.34 (2.25) s-1 (95% CI, 27.78-28.90, range 23.67-33.00 s-1) in females, 29.57 (3.20) s-1 (95% CI, 28.49-30.66, range 23.93-37.77 s-1) in males, and 28.72 (2.69) s-1 (range 23.67-37.77 s-1) in the whole group. R2* value in this particular population with a high proportion of young women did not exceed 38 s-1. In the absence of fibrosis or steatosis, liver stiffness and fat fraction did not show any relationship with R2*.
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Citations
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Journal Article
DOIRelationships of Serum Ferritin, Transferrin Saturation, and HFE Mutations and Self-Reported Diabetes Mellitus in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.
Ronald T. Acton, +13 moreUniversity of Alabama at Birmingham,Wake Forest University,London Health Sciences Centre,University of Western Ontario,Howard University,Veterans Health Administration,University of California, Irvine,Kaiser Permanente
- 16 Nov
2005-
Blood
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TL;DR: Serum ferritin concentration is associated with diabetes, even at levels below those typically associated with hemochromatosis or iron overload.
Journal Article
DOIQuantifying Bone Marrow Fat Fraction and Iron by MRI for Distinguishing Aplastic Anemia from Myelodysplastic Syndromes.
Zhaolong Zeng, +5 moreZhejiang Chinese Medical University
- 11 Jun
2021-
Journal of Magnetic Resonance Imaging
TL;DR: In this article, the authors evaluated the IDEAL-IQ images and measured FF and R2* in the left posterior superior iliac spine of patients with aplastic anemia and myelodysplastic syndrome.
Journal Article
DOIEvaluation of Hepatic Iron Overload Using a Contemporary 0.55 T MRI System.
Adrienne E. Campbell-Washburn, +9 moreNational Institutes of Health,Children's Hospital Los Angeles
- 20 Oct
2021-
Journal of Magnetic Resonance Imaging
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TL;DR: In this paper, a high-performance 0.55 T MRI system for evaluating patients with liver iron overload was presented. But, it is compromised by lower signal-to-noise ratio that reduces measurement precision.
Journal Article
DOINoninvasive Assessment of Liver Fibrosis by Magnetic Resonance Elastography in Patients with Rheumatic Disease on Long-Term Methotrexate Treatment
Arindam Nandy Roy, +2 more
- 01 Jan
2023-
Indian Journal of Rheumatology
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TL;DR: In this article, the authors used Magnetic Resonance elastography (MRE) to detect and quantify liver fibrosis in patients with rheumatic diseases on long-term methotrexate (MTX) therapy.
Journal Article
DOIQuantifying Liver Heterogeneity via R2*-MRI with Super-Paramagnetic Iron Oxide Nanoparticles (SPION) to Characterize Liver Function and Tumor
Danielle Lee, +2 more
- 27 Oct
2022-
Cancers
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TL;DR: In this article , super-paramagnetic iron oxide nanoparticles (SPIONs) are phagocytized by the hepatic Kupffer cells (KC) in the liver and shorten MRI signals within the volume of functional liver parenchyma (FLP) where KCs are found.
References
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Journal Article
DOICardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload
Lisa J. Anderson, +10 more
- 01 Dec
2001-
European Heart Journal
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TL;DR: Myocardial iron deposition can be reproducibly quantified using myocardial T2* and this is the most significant variable for predicting the need for ventricular dysfunction treatment, and early intensification of iron chelation therapy should reduce mortality from this reversible cardiomyopathy.
Journal Article
DOIMRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients
John C. Wood, +13 moreCalifornia Institute of Technology,Children's Hospital Los Angeles
- 15 Aug
2005-
Blood
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TL;DR: Both R2 and R2* can accurately measure hepatic iron concentration throughout the clinically relevant range of HIC with appropriate MRI acquisition techniques, despite significant differences in technique and instrumentation.
Journal Article
DOINoninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
Timothy G. St. Pierre, +8 more
- 15 Jan
2005-
Blood
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TL;DR: This study presents a readily available noninvasive method of measuring and imaging LICs in vivo using clinical 1.5-T magnetic resonance imaging units and revealed high degrees of sensitivity and specificity of R2 to biopsy LICs at the clinically significant LIC thresholds.
Journal Article
DOIValue of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis
Mark L. Bassett, +2 moreUniversity of Queensland
- 01 Jan
1986-
Hepatology
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TL;DR: It is concluded that chemical measurement of hepatic iron concentration, when corrected for the age of the subject, reliably distinguishes early hemochromatosis from alcoholic siderosis, and that there appears to be a threshold level of Hepatic iron above which there is a high risk of fibrosis.
Journal Article
DOINon-invasive assessment of hepatic iron stores by MRI.
Yves Gandon, +6 moreUniversity of Angers
- 31 Jan
2004-
The Lancet
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TL;DR: A highly T2-weighted GRE sequence was most sensitive, with 89% sensitivity and 80% specificity in the validation group, with an L/M ratio below 0.88, which allowed the procedure to detect all clinically relevant liver iron overload greater than 60 micromol/g.
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